FOA Title: 
Notice of Intent to Publish a Funding Opportunity Announcement for a Coordinating Center for Polygenic Risk Score (PRS) Methods and Analysis for Populations of Diverse Ancestry (U01 Clinical Trial Not Allowed)
Grant Type: 
Primary IC: 
Release Date: 
Oct 22 2019
Expiration Date: 
AC Source: 
Notice Intent Publish Funding Opportunity Announcement a Coordinating Center Polygenic Risk Score PRS) Methods Analysis Populations Diverse Ancestry U01 Clinical Trial Allowed) Notice Number: NOT-HG-20-006 Key Dates Release Date: October 22, 2019 Estimated Publication Date Funding Opportunity Announcement: January 13, 2020 First Estimated Application Due Date: June 02, 2020 Earliest Estimated Award Date: March 02, 2021 Earliest Estimated Start Date: June 02, 2021 Related Announcements NOT-HG-20-005 RFA-HG-20-001 RFA-HG-20-002 Issued National Human Genome Research Institute NHGRI) Purpose National Human Genome Research Institute intends issue Funding Opportunity Announcement FOA) solicit applications support Coordinating Center Polygenic Risk Score PRS) Methods Analysis Populations Diverse Ancestry. intended FOA be based a concept recently approved the National Advisory Council Human Genome Research accompanying discussion and Notice being provided allow potential applicants sufficient time develop meaningful collaborations responsive projects. FOA expected be published January, 2020 an expected application due date Summer, 2020. FOA utilize U01 activity code. Details the planned FOA provided below. Research Initiative Details goal the intended FOA to establish Coordinating Center provide overall logistical scientific support data science leadership a consortium will collaboratively generate refine PRS populations diverse ancestry integrating existing datasets genomic phenotype data a range complex diseases traits. Together Centers PRS Methods Analysis Populations Diverse Ancestry described a separate Notice), grantees funded under intended FOA form consortium the primary objectives of: 1) leveraging genetic diversity improve applicability PRS develop methods predict health disease risk across diverse populations, for broad range health disease measures; 2) optimizing integration large-scale, harmonized genomic phenotype data facilitate collaborative analysis, dissemination PRS-related data, development related methods resources. Grantees funded under intended Centers Coordinating Center FOAs work collaboratively address following scientific challenges opportunities: Standardizing genomic phenotype data, mapping existing ontologies. Developing methods and consensus approaches incorporate ancestry information PRS. Developing applying methods generate PRS diverse populations refining PRS improve risk prediction. Optimizing integration data according FAIR findable, accessible, interoperable, reusable) practices policies. Data sharing practices be developed enable analyses across consortium; data sharing outreach the scientific community also expected. Disseminating PRS results publicly the form summary statistics datasets, algorithms, publications, related resources. Validating PRS clinical settings engaging ongoing genomic medicine efforts. Identifying secondary uses the data related health disease research making data available such uses, consistent participants’ consent. Recognizing the funded PRS Centers not capture available diverse cohorts, CC also identify invite researchers representing high priority cohorts participate affiliate members provide limited genotyping analysis support them needed. Funding Information Estimated Total Funding NHGRI intends commit approximately 8.8 million FY21-FY25. Expected Number Awards Estimated Award Ceiling budget total costs no than 1.6 million/year HL([1] each five years Primary CFDA Numbers 93.172 Anticipated Eligible Organizations Public/State Controlled Institution Higher Education Private Institution Higher Education Nonprofit 501(c)(3) IRS Status than Institution Higher Education) Small Business For-Profit Organization than Small Business) State Government Indian/Native American Tribal Government Federally Recognized) County governments Indian/Native American Tribally Designated Organization Native American tribal organizations than Federally recognized tribal governments) U.S. Territory Possession Indian/Native American Tribal Government than Federally Recognized) Non-domestic non-U.S.) Entity Foreign Organization) Regional Organization Eligible Agencies the Federal Government Applications not being solicited this time.  Inquiries Please direct inquiries to: Lucia A. Hindorff, PhD, MPHNational Human Genome Research Institute NHGRI)