FOA Title: 
NOTICE OF INFORMATION: NIGMS Priorities for Sepsis Research
Grant Type: 
Primary IC: 
Release Date: 
Jul 29 2019
Expiration Date: 
AC Source: 
NOTICE INFORMATION: NIGMS Priorities Sepsis Research Notice Number: NOT-GM-19-054 Key Dates Release Date: July 29, 2019 Related Announcements NOT-GM-19-057 NOT-GM-20-028 Issued National Institute General Medical Sciences NIGMS) Purpose purpose this notice to inform potential applicants the National Institute General Medical Sciences NIGMS) areas sepsis research are special interest the Institute. NIGMS interested receiving applications will provide new knowledge the mechanistic complexity sepsis humans that test strategies translating knowledge improved diagnostics therapies sepsis patients. Background Despite decades intensive study, sepsis remains poorly understood condition limited diagnostic tools few specific treatments. working group the National Advisory General Medical Sciences Council NAGMSC) convened advise NIGMS how optimize research grant support preclinical clinical sepsis studies most effectively provide fundamental knowledge human sepsis to enable translation this knowledge improved diagnostic tools therapies. Based therecommendationsof NAGMSC Sepsis Working Group consistent its mission, NIGMS intends continue support fundamental discovery science basic clinical) relevant understanding mechanisms underlie heterogeneity is associated the pathogenesis resolution sepsis humans. NIGMS explore possibility providing support will enable access biospecimens data septic patients research purposes. NIGMS also coordinate other NIH institutes government agencies enable efficient clinical testing new diagnostics treatments sepsis. Research Objectives NIGMS seeks support sepsis research uses new emerging approaches, such clinical informatics, computational analyses, predictive modeling patients, new applications high-resolution high-throughput bioanalytical techniques materials obtained septic patients. Observational studies septic patients are designed provide new knowledge the biological mechanisms are associated the clinical heterogeneity disease resolution processes strongly encouraged. NIGMS also an interest studies explore use research organisms have traditionally employed models understanding sepsis. Development novel tools technologies sepsis research, detection, treatment encouraged. Specific topics research interest include, are limited the following: Understanding pathophysiology, treatment responses, clinical trajectories, initial resolution, long-term outcomes sepsis patients various levels biological organization molecule, cell, tissue, organism, etc.) Identifying, classifying, stratifying sepsis patients rapidly accurately various care settings Mechanistic studies using patients, patient-derived materials, clinical data sets will enable future development diagnostic treatment modalities of clinical data such that electronic health records develop predictive diagnostic algorithms to provide understanding patient heterogeneity treatment responses Multidisciplinary team approaches focused development new strategies sepsis detection diagnosis, patient stratification, treatment Analytical approaches combine different types data such molecular clinical functionally define sepsis subgroups endotypes Identification, characterization, validation sepsis-specific biomarkers particularly the context enabling endotyping strategies future evaluation diagnostics novel therapies Studies explore genetic determinants, biological variables sex, age, underlying health conditions), other relevant population characteristics race, ethnicity, socioeconomic status) associated differences sepsis endotypes, treatment responses, clinical trajectories, resolution, and/or long-term outcomes Application cutting-edge data science approaches such artificial intelligence machine learning fundamental clinical sepsis research questions Integration discovery approaches such genomics, proteomics, lipidomics, metabolomics, etc. elucidate molecular basis the pathophysiology resolution sepsis to molecularly define sepsis subgroups humans Mechanistic research employing non-traditional models discern pathways contribute the complex disparate responses are associated the pathophysiology resolution sepsis humans Basic clinical studies examine non-immunological contributions sepsis Development new assays technologies will enable efficient of sepsis biospecimens researchers clinicians Application new research methods models such asin silicoapproaches, cell culture, organoids early-stage testing validation potential sepsis diagnostics therapeutics Early stage research development projects through NIH SBIR/STTR program create commercializable tools technologies sepsis research, detection, therapy NIGMS considers following areas be low priority: Studies using rodent models sepsis unless uniquely well-justified terms potential providing novel insights human sepsis Clinical trials: general, NIGMS only consider support clinical trials are designed test strong mechanistic hypotheses include appropriate patient stratification. NIGMS expects scientific foundation all clinical trial applications be based data rigorously designed controlled human studies have published peer-reviewed literature. NIGMS unlikely support large-scale clinical trials unless NIH institutes/centers federal agencies provide joint support optimize trial efficiency, recruitment, oversight. Application Submission Information Applications response this Notice be submitted through any activeNIGMS Funding Opportunity Announcement.All instructions the selected Funding Opportunity Announcement must followed. Investigators planning submit application strongly encouraged discuss proposed research the scientific contact listed below well advance the application due date. Inquiries Please direct inquiries to: Sarah E. Dunsmore, Ph.D.National Institute General Medical Sciences NIGMS)