FOA Title: 
Request for Information (RFI): Inviting Comments and Suggestions on the Environmental influences on Child Health Outcomes (ECHO) Program (the National Children's Study Alternative)
Grant Type: 
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Release Date: 
Jul 13 2015
Expiration Date: 
AC Source: 
Request Information RFI): Inviting Comments Suggestions the Environmental influences Child Health Outcomes ECHO) Program National Children's Study Alternative) Notice Number: NOT-OD-15-117 Key Dates Release Date:   July 13, 2015 Response Date: August 14, 2015 Related Announcements None     Issued National Institutes Health NIH) Purpose Notice a time-sensitive Request Information RFI) inviting comments suggestions the proposed plan the Environmental influences Child Health Outcomes ECHO) program. NOTE: is important read entire RFI notice ensure adequate response prepared to a full understanding how response be utilized. Background 2000, Congress authorized study children's health development - National Children's Study NCS) - part the Children's Health Act. Due concerns NIH leadership stakeholders, June 2014 Institute Medicine IOM) asked review NCS, proposed national longitudinal study environmental influences including physical, chemical, biological, psychosocial) child health development. resulting IOM report expressed concerns the study's design, management, oversight structure, anticipated cost. an outcome the IOM report, launch the Main Study the NCS put hold, a working group the Advisory Committee the Director ACD) NIH, included experts the fields pediatric environmental health, charged reviewing NCS evaluate feasibility. December 2014, ACD recommended that, while overall goals the NCS should remain priority future scientific support, NCS not feasible currently outlined. After careful consideration discussion NIH senior leadership, Dr. Collins accepted ACD's recommendation discontinue NCS. make best of fiscal year FY) 2015 appropriated funds, NIH leadership staff worked diligently identify opportunities address challenges the intersection pediatric environmental health through alternative approaches are consistent the original goals the NCS, including establishing compelling new programs, integrating existing programs, enhancing programs incorporating comprehensive environmental assessments. major focus the comprehensive effort on development tools enhance measurement environmental exposures e.g., physical, chemical, biological, psychosocial) facilitate research across of initiatives programs. Another key component the plan studying environmental influence placental in utero development, the goal identifying seeds" future diseases conditions. Finally, leveraging extant programs, plan aims expand examination environmental influences later child development. keeping the spirit the NCS, initiatives aim address critical goal understanding impact environmental influences children's health development advance field our knowledge. Going forward, overarching goal the FY 2016 plan to leverage expand extant cohorts address new research questions investigate longitudinal impact prenatal, perinatal, postnatal environmental exposures pediatric health outcomes high public health impact. do so, NIH proposes support multiple synergistic, longitudinal studies using extant cohorts represent variable environmental exposures e.g., physical, chemical, biological, psychosocial, natural built environments) will share standardized research questions focus four key pediatric outcomes. longitudinal studies collect same standardized, targeted data Core Elements) a component the project, will managed through Coordinating Center. Coordinating Center, will include analytical data science component, be supported through cooperative agreement NIH. will overseen a Steering Committee NIH staff, heads the Coordinating Center, the PIs the studies. Core Elements be addressed across studies: Demographics e.g., race, gender, ethnicity, socioeconomic status, geographic location/diversity e.g., IDeA States)] Typical early development e.g., growth, milestones, microbiome, sleep, nutrition, activity level] Epigenetic influences early childhood development e.g., maternal exposome"] Environmental factors e.g., physical, chemical, biological utero), psychosocial, natural built environments] Four focus areas address research questions specific critical pediatric conditions health outcomes assess range functioning over time. Focus Areas are: Upper lower airway e.g., asthma, allergies, sleep disordered breathing) Obesity e.g., nutrition, diabetes, metabolic risk factors) Pre-, peri-, postnatal outcomes e.g., birth defects, childhood outcomes) Neurodevelopment e.g., autism, ADHD, depression, social/behavioral development, cognition] FY 2016 plan aims provide flexibility opportunity investigate key questions interest the intersection environmental health pediatric research, while also leveraging additional features capabilities the studies. example, studies could: take maximal advantage existing tissue banks collected across pregnancy e.g., cervicovaginal secretions, maternal DNA, cord blood, placenta) data sets funding additional analyses; serve a test bed validating new technologies, tools, approaches efficient effective environmental pediatric monitoring; systems approaches develop multi-variable models predict disease development; recruit future pregnancies investigate outcomes second children serve a comparison cohort first pregnancy children. an additional research opportunity, FY16 plan also proposes create IDeA States National Pediatric Clinical Research Network, could: Address access gaps rural children through national network pediatric research embedded IDeA locations Link existing IDeA state centers experts clinical trials Information Requested RFI seeks input stakeholders throughout extramural scientific community the general public regarding FY16 ECHO plan. NIH seeks comments any all of, not limited to, following topics: Core Elements: Potential benefits, drawbacks, areas consideration leveraging existing cohorts collect standardized data elements Additional core elements be considered Considerations harmonizing data across cohorts High impact areas opportunity addition those listed Anticipated advances and/or considerations implementing state-of-the-art data collection analytic methodologies throughout duration the study four Focus Areas: Suggestions existing research studies resources might address or of areas, including description the study resource e.g., sample size, demographic information, major health behavioral outcomes, environmental exposures, success or potential follow-up through childhood, available biologic environmental specimens) additional IDeA States opportunity to Submit Response comments must submitted electronically the submission website Responses longer 300 words MS or pdf format) must received 11:59:59 pm EST) August 14, 2015. will an electronic confirmation acknowledging receipt your response. Responses this RFI voluntary. not include any proprietary, classified, confidential, trade secret, sensitive information your response. responses be reviewed NIH staff, individual feedback not provided any responder. Government use information submitted response this RFI its discretion. Government reserves right use any submitted information public NIH websites, reports, summaries the state the science, any possible resultant solicitation(s), grant(s), cooperative agreement(s), in development future funding opportunity announcements. RFI for information planning purposes only shall be construed a solicitation, grant, cooperative agreement, as obligation the part the Federal Government, NIH, individual NIH Institutes Centers. Government not pay the preparation any information submitted for Government's of such information. basis claims against U.S. Government shall arise a result a response this request information from Government's of such information. look forward your input hope you share RFI document your colleagues. Inquiries Please direct inquiries to: Email:
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