Cloud Resources Program | Data Science at NIH

Cloud computing assumes a pivotal role in biomedical research, offering a range of critical benefits. It provides the flexibility of scalable computing power and storage, access to extensive biomedical datasets, cutting-edge software and hardware resources, and user-friendly data sharing capabilities. Particularly noteworthy is its ability to level the playing field for institutions with limited on-premises computing facilities. Many NIH researchers stand to gain significantly from cloud computing technology, as it addresses their evolving computational needs. Additionally, many NIH research projects can experience transformative enhancements by harnessing the innovative capabilities of the cloud.

To take the advantage of the opportunities, the NIH Office of Data Science Strategy launched this program to support NIH researchers in leveraging cloud resources in their research activities.

NOSIs:

2023: NOT-OD-23-070, expired on 4/12/2023
2024, 2025, 2026: NOT-OD-24-078, expiration date 6/19/2026

High-Value Datasets (HVD) Program:

HVD 2020, expired on 1/15/2020
HVD 2021, expired on 1/10/2021
HVD 2022, expired on 2/1/2022
HVD 2023, expired on 2/1/2023
HVD 2024, expired on 2/13/2024
HVD 2025, expired on 2/5/2025

STRIDES Cloud Credits Program (SCC):

SCC 2025, round 1, expired on 11/15/2024

PI meetings:

2024 ODSS Cloud Supplement Program PI Meeting

Awardee projects and their descriptions are available below.

View HVD 2020 Awardees

HVD 2020 Awardees
Principal Investigator	Project Title	NIH IC
Sandhya Xirasagar	Using the AWS Cloud for Improved PII Data Security and Cross-IC Collaboration to Develop Gene Prioritization and Text Mining Pipelines for the Genome Research Integration System	NIAID
Hari Shroff	Evaluation of cloud computing for imaging and microscopy datasets	NEI & NIBIB
Valentina Di Francesco	AnVIL & STRIDES	NHGRI
Jim Gnadt	Zebrafish Dataset Hosting Supplement	NINDS
Krista Zanetti	COMETS Analytics	NCI
Geoffrey Tobias	DCEG Analytic Tools Suite	NCI
Jonathan Kaltman	Migrating imaging datasets and tools to the NHLBI BioData Catalyst	NHLBI
Weiniu Gan	Single-cell Omics based Reference Lung resource (RefLung)	NHLBI
Keyvan Farahani	A Sustainable Medical Imaging Challenge Cloud Infrastructure (MedICCI)	NCI
Jeff Shilling	NCI IRP Cloud Migration: Genomics, Chemistry, and Imaging	NCI
Quan Chen	Facilitating access of immunological data in ImmPort for analyses	NIAID

View HVD 2021 Awardees

HVD 2021 Awardees
Principal Investigator	Project Title	NIH IC
Charlene Schramm	Using Seven Bridges’ CAVATICA to empower use of the INCLUDE DCC platform	OD
Adrienne Campbell	Inline image reconstruction of dynamic 3D data using a GPU-enabled cloud implementation	NHLBI
Greg Farber	Migrating Human Connectome Analysis Tools to the Cloud	NIMH
Deborah Duran	NIMHD Algorithmic Auditing Tool and Centralized Research Collaboration Platform to Assess and Mitigate Healthcare Decision Biases Impacting Marginalized Populations	NIMHD
Kim Pruitt	SRA RNA-seq precomputed alignments and gene expression counts	NLM
Daniel Veltri, Andrew Oler	Develop a Scalable and Reusable Framework for State-of-the-Art Structural Variant Calling of Whole Genome Sequencing Data	NIAID
Daniel Reich	Medical Image processing and structured storage	NINDS
Wang, Xujing	Cloud migration of data and data analysis platform of The Environmental Determinants of Diabetes in The Young Study (TEDDY)	NIDDK
Tanja Davidsen	NCI CRDC Cloud Transfer of TP53 Website and Database	NCI
Wang, Xujing	Migration of Core Applications from the NIDDK information Network (dkNET)	NIDDK
Jeff Shilling	NCI IRP Cloud Migration: Imaging and Chemistry	NCI
Valentina Di Francesco	Telomere-to-Telomere Consortium Analyses on the NHGRI AnVIL	NHGRI
Arvydas Maminishkis	Artificial Intelligence Based Morphometric Analysis of Cells	NEI
Mehdi Pirooznia	Cloud implementation of TensorFlow machine learning framework for SNP and indel variant calling on exomes and whole genomes sequencing	NHLBI
Debra Babcock	Parkinson's Disease Biomarkers Program (PDBP)	NINDS
Weiniu Gan	National Sleep Research Resource	NHLBI

View HVD 2022 Awardees

HVD 2022 Awardees
Principal Investigator	Project Title	NIH IC
Andrew Singlet, Cornelis Blauwendraat	Long-read DNA sequencing of neurodegenerative disorders	NIA
Qian Zhu	Rare Disease Alert System	NCATS
Ewy Mathé	Public Substance Registration Using the Global Substance Registration System (GSRS)	NCATS
Valentina Di Francesco	Text mining in the Cloud	NHGRI
Ronald M. Summers	Small Bowel Segmentation	CC
Javed Khan MD	Oncogenomics Pipeline & Databases for Childhood Cancer Data Initiative (CCDI) and other Pediatric Cancers	NCI
Valentina Di Francesco	Long Read Variant Frequency Database on AnVIL	NHGRI
Janelle Cortner	Accelerating External Sharing of NCI IRP Imaging Data & AI Models via Platform Connectivity	NCI
Iman Martin	Building a cross-study data set for the PRIMED consortium	NHGRI
Johnny Tam, Hari Shroff	Cloud Computing for Optical Image Restoration and Intramural Training	NEI & NIBIB
Kirsten Herrick, Christie Kaefer	Automated Self-Administered 24-hour Dietary Assessment Tool (ASA24)	NCI
Janelle Cortner	Accelerating External Sharing of NCI IRP Genomic Data via Platform Connectivity	NCI
Janelle Cortner	Leveraging Intramural NCI Data Platforms for Accelerated Data Sharing	NCI
Lisa Cunningham, PhD	Generation of an NIH-wide Clinical Database of Hearing and Balance Function	NIDCD

View HVD 2023 Awardees

HVD 2023 Awardees
Principal Investigator	Project Title	NIH IC
Zhiyong Lu	Scaling up literature annotations with cloud computing in PubTator 3.0	NLM
Keith Shockley, Alison Motsinger-Reif	Genome-wide analysis using cloud computing in the All of Us Researcher Workbench	NIEHS
Stephen Brooks, Darrick Akiyama	NIAMS Hybrid Cloud Computing Pilot	NIAMS
Elizabeth Powell	Alcoholism Solutions: Synthesizing Information to Support Treatments (ASSIST 2.0)	NIAAA
Scott Auerbach	ToxPipe: Semi-Autonomous AI Integration of Diverse Toxicological Data Streams	NIEHS
Joseph Marcotrigiano	Cryo-EM data processing on the cloud	NIAID
Javed Khan	Oncogenomics Pipeline & Databases for Childhood Cancer Data Initiative (CCDI) and other Pediatric Cancers	NCI

View HVD 2024 Awardees

HVD 2024 Awardees
Principal Investigator	Project Title	NIH IC
Yang Fann	Exploring the Potential of Large Language Models for IRP Operations and Research	NINDS
Qian Zhu	Accelerating Rare Disease Research via Rare Disease Alert System (RDAS)	NCATS
Joseph Marcotrigiano	Optimization of cloud computing for cryo-EM data processing	NIAID
Robert J. Lederman	Optimization of Cardiovascular Interventional MRI Devices via Cloud-Based High-Fidelity Electromagnetic Simulations	NHLBI
Cliff Wong, Emily Greenspan	HPC MuMMI for Commercial AWS Cloud Proof of Concept	NCI
Mitchell Machiela	LDlink	NCI
Vipul Periwal	Faithful low-dimensional representations for modeling imbalanced data sets	NIDDK
Evan Bolton	PubChemRDF in Cloud	NLM
Jeffrey Beck	Using Generative AI in the cloud to develop a training set for new MeSH terms for the MEDLINE Medical Text Indexing System	NLM
Naoko Mizuno	Exploration of cloud computing for cryo-EM/ET analysis pipeline	NHLBI
Rebecca Troisi	Development of epidemiological study data platforms to support FAIR research practices	NCI
Peter Kraft	FlowIQ: A workflow cloud migration toolkit	NCI
Johnny Tam	Large scale image data handling in the cloud	NEI
Javed Khan, MD	Oncogenomics Pipeline & Databases for Childhood Cancer Data Initiative (CCDI) and other Pediatric Cancers	NCI
Xiaofang Jiang	Predicting Phage-Host Range Using Deep-Learning	NLM
Ronald M. Summers	Processing Radiology Reports with GPT-4	CC
Anirban Banerjee	Structural studies of integral membrane enzymes and transmembrane transporters	NICHD
Neil Hanchard	Cloud-computing to enable global admixture mapping in childhood hypertension	NHGRI
Keith Shockley, Alison Motsinger-Reif	Variant Calling and Data Dissemination in the All of Us Cloud Computing Resource	NIEHS

View HVD 2025 Awardees

HVD 2025 Awardees
Principal Investigator	Project Title	NIH IC
Granger Sutton	Cloud-based Medical Imaging Data Analysis Using Artificial Intelligence	NCI
Matthew McAuliffe	BRICS Cloud	CIT
Jenny Hinshaw	Cloud computing for structural studies of large dynamin helical assemblies	NIDDK
Anand Swaroop	Cloud-Based Training of Large Language Models for Retinal Transcriptome Analysis	NEI
Fausto Vela	REShAPE3D: Expanding Dimensions in RPE Analysis	NEI
Cliff Wong (COR) Emily Greenspan (PI)	HPC MuMMI for Commercial AWS Cloud Phase 2 – Full Feature Proof of Concept	NCI
Mia Gaudet	Centralized Orchestration of Serverless Analytics Pipelines Using Apache Airflow in Google Cloud	NCI
Di Xia	Structural Mechanisms of Cellular Drug Resistance	NCI
Ivan Ovcharenko	Advanced AI models of disease-causative genome variants.	NLM
Zhiyong Lu	An LLM Powered Tool for Expert Search within NIH IRP	NLM
Haiming Cao	Development of an Artificial Intelligence (AI) Agent for Elucidating the Molecular and Disease Mechanisms of Human Long Non-Coding RNAs (lncRNAs)	NHLBI
Keith Shockley, Alison Motsinger-Reif	Support for bioinformatics pipelines for high value genotype calling at biobank scale in the All of Us Researcher Workbench	NIEHS
Mario J. Borgnia	One stop resource for cryo EM data collection and processing	NIEHS
Justine Buschman	NIAMS EP DEA Specialized AI Agents Pilot	NIAMS

View SCC 2025 Round 1 Awardees

SCC 2025 Round 1 Awardees
Principal Investigator	Project Title	NIH IC
Robert Lederman	AI-powered real-time 3D visualization for X-ray cardiac intervention	NHLBI
Mario Borgnia	Determine structures of macromolecular complexes using cryogenic electron microscopy (CryoEM)	NIEHS
Dimitrios Metaxotos	Leverag GPU-accelerated frameworks to optimize large-scale data and network analysis workflows	NCATS
Naomi Ohashi	Atom Modeling PipeLine (AMPL) and Generalized Generative Molecular Design (GMD)	NHLBI
Gayla Poling	Expand nHEAR by integrating additional specialized hearing/vestibular data from the AVCRS and to further streamline data migration processes from ongoing and future projects	NIDCD
Brad Bower	Understand the Impact of NIH Investment on FDA Cleared Products	NIBIB
Darrick Akiyama	NIAMS Artificial Intelligence Pilot	NIAMS
Saman Moshafi	Computational Resources for Cancer Research (CRCR) information system	NCI
Johanna Goderre Jones	National Childhood Cancer Registry (NCCR) data platform	NCI
Mitchell Machiela	Assess linkage disequilibrium by querying SNPs/indels	NCI
Joseph Marcotrigiano	Cryo Electron Microscope Data Processing	NIAID

View NOT-OD-23-070 Awardees

NOT-OD-23-070 Award Recipients
Principal Investigator	Institution	Project Title	NIH IC
DURA-BERNAL, SALVADOR	SUNY DOWNSTATE MEDICAL CENTER	Dissemination of a tool for data-driven multiscale modeling of brain circuits	NIBIB
KUMAR, POORNIMA	MCLEAN HOSPITAL	Building Reinforcement Learning and Normative Models in the Cloud	NIMH
OBUA, CELESTINO	MBARARA UNIVERSITY/SCIENCE/TECHNOLOGY	MUST Data Science Research Hub (MUDSReH) - Democratized Trusted Research Environment (dTRE)	FIC
MORSE, GENE D	STATE UNIVERSITY OF NEW YORK AT BUFFALO	Exploration of Cloud Solutions to Enhance Global Infectious Diseases Research Training Program Activities	FIC
CHERRY, J. MICHAEL	STANFORD UNIVERSITY	Support for the use and evaluation of large cloud-based genomic datasets	NHGRI
LIU, TIEMING	OKLAHOMA STATE UNIVERSITY STILLWATER	Empowering Cloud Computing for Non-image-based Diabetic Retinopathy Screening by Designing an EHR-oriented Incremental Learning Framework	NEI
KESSELMAN, CARL	UNIVERSITY OF SOUTHERN CALIFORNIA	Hybrid- and Multi-Cloud Storage Strategies for Cost-effective Deployment of Data Resources	NIDCR
ZORN, AARON M	CINCINNATI CHILDRENS HOSP MED CTR	Cloud implementation of Xenbase the Xenopus model organism knowledgebase	NICHD
RESNICK, ADAM CAIN	CHILDREN'S HOSP OF PHILADELPHIA	Enhancing CBTN digital pathology processing pipeline through the use AWS cloud-based services to enable automation, parallel processing, and rapid use of AI/ML analytics	NICHD
VALERIUS, MICHAEL TODD	BRIGHAM AND WOMEN'S HOSPITAL	ATLAS-D2K - Exploring Cloud Optimization	NIDDK
BOBASHEV, GEORGIY	RESEARCH TRIANGLE INSTITUTE	Supplement for Cloud Computing: Opioid Policy Models	NIDA
POWDERLY, WILLIAM G.	WASHINGTON UNIVERSITY	Exploration of Cloud-based High Performance Computing	NCATS
YIN, YANBIN	UNIVERSITY OF NEBRASKA LINCOLN	Exploration of cloud computing for CAZyme research	NIGMS
SAFO, SANDRA E	UNIVERSITY OF MINNESOTA	MultiViewPortal: Towards a Scalable Web Application for Multiview Learning	NIGMS
HOWE, WILLIAM MATTHEW	VIRGINIA POLYTECHNIC INST AND ST UNIV	An evaluation of the costs and benefits of cloud computing for modern systems neuroscience	NIDDK
BROOKS, STEPHEN	NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES	NIAMS Hybrid Cloud Computing Pilot	NIAMS
POWELL, ELIZABETH	NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM	Alcoholism Solutions: Synthesizing Information to Support Treatments (ASSIST 2.0)	NIAAA
ARNAOUT, RIMA	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	Developing FAIR practices for cloud-enabled AI deployment for prospective testing	NHLBI
YU, BING	UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON	Development of a cloud-based analytical tool for polygenic risk score and its implication in heart failure research	NHLBI
KOBER, KORD MICHAEL	UNIVERSITY OF CALIFORNIA, SAN FRANCISCO	An Evaluation of Cloud Computing for Symptom Science Research: Moving Genomics and Machine Learning Analyses of Cancer Chemotherapy-Related Fatigue to the Cloud	NCI
TAVTIGIAN, SEAN VAHRAM	UNIVERSITY OF UTAH	Cloud Enabled, Rigorous, Functional Assay Calibration (CERFAC)	NCI
KIEHL, KENT A	LOVELACE BIOMEDICAL RESEARCH INSTITUTE	Cloud based neuroimaging analysis for identifying traumatic brain injuries and related changes	NINDS
RUEBEL, OLIVER	UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB	Evaluation and optimization of NWB neurophysiology software and data in the cloud	NINDS
LU, ZHIYONG	NATIONAL LIBRARY OF MEDICINE	Scaling up literature annotations with cloud computing in PubTator 3.0	NLM
SHOCKLEY, KEITH/MOTSINGER-REIF, ALISON	NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES	Genome-wide analysis using cloud computing in the All of Us Researcher Workbench	NIEHS
AUERBACH, SCOTT	NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES	ToxPipe: Semi-Autonomous AI Integration of Diverse Toxicological Data Streams	NIEHS
MARCOTRIGIANO, JOSEPH	NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES	Cryo-EM data processing on the cloud	NIAID
COOPER, LEE	NORTHWESTERN UNIVERSITY AT CHICAGO	Cloud strategies for improving cost, scalability, and accessibility of a machine learning system for pathology images	NLM
KARRIKER-JAFFE, KATHERINE J.	RESEARCH TRIANGLE INSTITUTE	Supplement for Cloud Computing: Alcohol Use Disorder Treatment Simulation	NIAAA
KHAN, JAVED	NATIONAL CANCER INSTITUTE	Oncogenomics Pipeline & Databases for Childhood Cancer Data Initiative (CCDI) and other Pediatric Cancers	NCI
KUMAR, VIVEK	JACKSON LABORATORY	Google Cloud Pipeline for mouse behavior and frailty assessment for the aging research community	NIA