CDM and FHIR® Harmonization Resources

This webpage contains useful resources and tools for researchers exploring the use of the Health Level Seven International (HL7®) Fast Healthcare Interoperability Resources (FHIR®) specification and common data models (CDMs) used in research. FHIR can be used in conjunction with CDMs to capture, integrate, and exchange clinical data for research purposes and to enhance sharing capabilities of research data.

CDM and FHIR Harmonization Resources

The table below contains mappings, mapping tools, and educational resources to aid clinical researchers who are interested in harmonizing clinical data and FHIR for research. The resources are focused on harmonizing FHIR with four CDMs used by researchers:

  1. Informatics for Integrating Biology & the Bedside (i2b2) CDM,
  2. Observational Medical Outcomes Partnership (OMOP),
  3. Patient-Centered Outcomes Research Network (PCORnet) CDM, or
  4. Sentinel CDM.
CDM and FHIR Harmonization Resources
Resource Name Focus of Resource Resource Description Related CDMs Source Name Source Description Funding
CDM - FHIR Gap Analysis Mappings

List of mappings between FHIR and three CDMs:

  1. ACT(i2b2) to FHIR Mappings Table,
  2. OMOP to FHIR Mappings Resources, and
  3. PCORnet(v4.1) to FHIR Mappings Table.

i2b2, OMOP, PCORnet

CD2HThe National Center for Data to Health (CD2H)
Data Harmonization Project
The
CD2HThe National Center for Data to Health (CD2H)
Data Harmonization project, part of the CD2H Next Generation Data Repository Core, identifies and curates resources and tools that enable a common framework for rendering and querying clinical data. CD2H accelerates advancements in informatics by using
FAIRFindability, Accessibility, Interoperability, and Reuse (FAIR)
principles to promote collaboration across the
CTSAClinical and Translational Science Awards (CTSA)
Program.

NIH

Federated Data Query Workshop

Educational

Presentations with video and slides from a two-day workshop focused on data harmonization and federated query and hosted by the
CD2HThe National Center for Data to Health (CD2H)
Data Harmonization Working Group.

i2b2, OMOP, PCORnet

CD2HThe National Center for Data to Health (CD2H)
Data Harmonization Project
The
CD2HThe National Center for Data to Health (CD2H)
Data Harmonization project, part of the CD2H Next Generation Data Repository Core, identifies and curates resources and tools that enable a common framework for rendering and querying clinical data. CD2H accelerates advancements in informatics by using
FAIRFindability, Accessibility, Interoperability, and Reuse (FAIR)
principles to promote collaboration across the
CTSAClinical and Translational Science Awards (CTSA)
Program.

NIH

OMOPonFHIR

Mapping Tools

A Java-based mapping platform that supports bidirectional read and write capabilities between FHIR versions
DSTUDraft Standard for Trial Use
2,
STUStandard for Trial Use
3,
R4Release 4 (R4)
and OMOP v.5.3.1 and v6.0.

OMOP

OMOPonFHIR

OMOPonFHIR, also known as Georgia Tech’s  FHIR and OMOP CDM mapping platform, supports various mapping combinations between versions of FHIR and the OMOP CDM.

Georgia Tech Research Institute

CAMP FHIR Application

Mapping Tools

A custom software application that uses
SQLStructured Query Language (SQL)
scripts to automate the transformation of data from i2b2 (using ACT ontology) or the PCORnet CDMs to FHIR. The scripts can be modified to accommodate additional CDMs and different versions of CDMs and FHIR.

i2b2, PCORnet

Biomedical Data Translator Program

NCATSNational Center for Advancing Translational Sciences (NCATS)
launched the Biomedical Data Translator Program to overcome challenges (e.g., compartmentalization of data, disparate data types, lack of semantic harmonization) in application of the myriad biomedical datasets that are available today for greater public good.

NIH, NCATS’ Biomedical Data Translator Program, Center for Translational Science Program, UNC Chapel Hill

COVID-19 Mapping Spreadsheet

Mappings

A spreadsheet of data elements, identified by the COVID-19 Evidence Accelerator Collaborative Initiative, mapped to the Sentinel CDM, PCORnet CDM, i2b2/ACT CDM, OMOP, and FHIR Resources.

i2b2, OMOP, PCORnet, Sentinel

COVID-19 Real World Data Elements Harmonization Project

This project aims to harmonize a list of COVID-19 data elements with several CDMs and open standards. The project is being conducted under the COVID-19 Evidence Accelerator Collaborative initiative led by Reagan-Udall Foundation,
FDAU.S. Food and Drug Administration
, and Friends of Cancer Research.

FDA

Common Data Model Harmonization FHIR IG

Mappings, Mapping Tools

The FHIR
IGImplementation Guide (IG)
contains guidance for mapping and translating observational data into the FHIR format. The IG contains mappings between the various CDMs and relevant FHIR Resources and profiles.

i2b2, OMOP, PCORnet, Sentinel

Common Data Model Harmonization Project

A collaborative project between three federal government agencies (
FDAU.S. Food and Drug Administration
,
ONCOffice of the National Coordinator for Health Information Technology (ONC)
, and NIH), including three NIH institutes and centers (NCI,
NCATSNational Center for Advancing Translational Sciences (NCATS)
, and
NLMNational Library of Medicine (NLM)
), that set out to harmonize four existing CDMs to support research and analysis across multiple data networks.

Patient-Centered Outcomes Research Trust Fund

Data Model Harmonization Subgroup Confluence

Educational

Minutes and supporting documents from a subgroup of the FHIR-OMOP Working Group. Their objectives are to, 1) develop canonical mappings and
ETLextract, transform, and load (ETL)
specification, 2) maximize adoption for mappings, profiles, and
IGImplementation Guide (IG)
s; and 3) refine, simplify, streamline, and accommodate additional use cases.

OMOP

FHIR-OMOP Collaborative

A collaboration between HL7 and the
OHDSIObservational Health Data Sciences and Informatics (OHDSI)
network to create a single CDM by integrating FHIR and OMOP.

HL7 and OHDSI

FHIR-OMOP Collaborative Confluence

Educational

Minutes, supporting documents, and announcements from the FHIR-OMOP Working Group.

OMOP

FHIR-OMOP Collaborative

A collaboration between HL7 and the
OHDSIObservational Health Data Sciences and Informatics (OHDSI)
network to create a single CDM by integrating FHIR and OMOP.

HL7 and OHDSI

This page last reviewed on November 1, 2022