Administrative Supplements to Support Enhancement of Software Tools for Open Science

About the Administrative Supplements to Support Enhancement of Software Tools for Open Science

As part of their research projects, investigators often produce innovative, scientifically valuable software tools. Frequently, these valuable tools cannot be supported long-term or are developed under conditions that aren’t optimal for reuse. In an effort to address this, the National Institutes of Health (NIH) Office of Data Science Strategy (ODSS) and 24 institutes and centers (ICs) at NIH announced a notice for administrative supplements to enhance software tool development for open science (NOT-OD-20-073) in 2020. On April 7, 2021, ODSS announced "Additional Administrative Supplements Available to Support Enhancement of Software Tools for Open Science (NOT-OD-21-091)" with a due date of May 15, 2021.

These supplements will

  • support robustness, sustainability, and scalability of existing biomedical research software tools and workflows.
  • invest in research software tools with recognized value in a scientific community to enhance their impact by leveraging best practices in software development and advances in cloud computing.
  • support collaborations between biomedical scientists and software engineers to enhance the design, implementation, and “cloud-readiness” of research software.

Twenty-eight awards were made in the fall of 2020 to principal investigators at 26 different institutions across the United States. Awardee projects and their descriptions are available below.

Award Recipients

Principal Investigator


Project Title


Apkar Vania Apkarian

Northwestern University at Chicago

Brain Pathophysiology of Osteoarthritis Pain


Sylvain Bouix, Marek Kubicki, Nikolaos Makris

Brigham and Women's Hospital

High Resolution, Comprehensive Atlases of the Human Brain Morphology


Gregory R. Bowman

Washington University

MSMs, adaptive sampling, and data sharing on the cloud


Laurel H. Carney

University of Rochester

Auditory Processing of Complex Sounds


Brian Yuan Chen

Lehigh University

Algorithmic identification of binding specificity mechanisms in proteins


Gerardo Andres Cisneros

University of North Texas

Investigation of DNA Modifying Enzymes by Computational Simulations: Development and Applications


Gaudenz Danuser

UT Southwestern Medical Center

Functional causality in regulating cell morphogenesis


Shireen Youssef Elhabian

University of Utah

ShapeWorks in the Cloud


Melanie Fried-Oken

Oregon Health & Science University

Enhancing an open-source brain-computer interface software for greater adoption and physiologic data sharing


Ryan Gutenkunst

University of Arizona

Joint inferences of natural selection between sites and populations


John H L Hansen, Ruth Y. Litovsky, Mario A. Svirsky

University of Texas Dallas

CCI-Mobile: Signal Processing Advancements for Cochlear Implant Users in Naturalistic Environments


Carl Kesselman, Yang Chai

University of Southern California

Creating Scalable, Reliable, Sustainable Infrastructure for FAIR Data


Steven H. Kleinstein

Yale University

Enhancing the cloud-readiness of the Immcantation framework for B cell receptor repertoire sequencing analysis


Francine Laden, Francesca Dominici

Harvard School of Public Health

Relationship Between Multiple Environmental Exposures and CVD Incidence and Survival: Vulnerability and Susceptibility


Suzanne M. Leal, Andrew Dewan, Paul Livermore Auer

Columbia University Health Sciences

Innovative approaches to elucidate the genetic etiology of age-related hearing impairment and tinnitus


Yaling Liu

Lehigh University

Hemolysis Prediction Software Development


Shaun Aengus Mahony, Franklin B. Pugh

Pennsylvania State University-University Park

Genome-wide structural organization of proteins within human gene regulatory complexes


Nadine Martin

Temple University of the Commonwealth

Translation and Clinical Implementation of a Test of Language and Short-term Memory (STM) in Aphasia


David P. Miller

Wake Forest University Health Sciences

Effectiveness and Implementation of mPATH-CRC:  A Mobile Health System for Colorectal Cancer Screening


David Lowell Mobley

University of California-Irvine

Advancing predictive physical modeling through focused development of model systems to drive new modeling innovations


Matteo Pellegrini

University of California Los Angeles

Enhancing the International Molecular Exchange (IMEx): Providing an Improved Community-Oriented Molecular Interactions Resource


Bjoern Peters

La Jolla Institute for Immunology

Developing computational models to predict the immune response to B. pertussis booster vaccination


David Claude Richardson

Duke University

Extending MolProbity Diagnosis & Healing Methods to Empower Better CryoEM & Xray Models at 2.5-4A Resolution, plus Versioned, Redeposited GEMS for Import


Pinaki Sarder

State University of New York at Buffalo

Human AI Loop in Cloud for Renal Pathology Informatics


Michael R. Shirts, John Damon Chodera

University of Colorado

Open Data-driven Infrastructure for Building Biomolecular Force Field for Predictive Biophysics and Drug Design


Louis J. Soslowsky

University of Pennsylvania

Differential Roles of Collagen V in Establishing the Regional Properties in Mature and Aging Supraspinatus Tendons


Andre Jan Willem, Martha Holmes, Mamadou Kaba

Massachusetts General Hospital

Neuroimaging and gut microbiome markers of development in HIV-exposed uninfected infants


Xiaoyin Xu, Geoffrey Young

Brigham and Women's Hospital

Computer aided diagnosis of cancer metastases in the brain


This page last reviewed on April 9, 2021